Clinic researchers and collaborators tie genetic variant to risk of major depressive disorder

In a published paper released today in Proceedings of the National Academy of Sciences, Clinic for Special Children researchers and collaborators from Columbia University and Regeneron Genetics Center discover a rare mutation in a gene that increases the risk of major depressive disorder.

Major depressive disorder is a leading cause of disability worldwide and can affect people from all communities and backgrounds. Working closely with partners at Columbia University and Regeneron Genetics Center, the Clinic for Special Children research team discovered a rare mutation in a gene called GPR156 that increases susceptibility to major depression nearly three-fold and can be passed down through the generations. We found that GPR156 is expressed in a deep part of the brain called the medial habenula, which is known to play a crucial role in behavioral responses to stress. This work deepens our understanding of the causes of depression and introduces a new target for its treatment,” shares Dr. Kevin A. Strauss, Head of Therapeutic Development at the Clinic for Special Children.

Read the paper HERE

Read the press release HERE

Register today for the 2025 Clinic for Special Children 5k!

Join us on May 17, 2025!

Runners, joggers, and walkers are invited to participate in the Clinic for Special Children 5k presented by Nemours Children’s Health – a 3.1-mile course along rolling scenic roads, winding through Lancaster County farmland, venturing past Amish schoolhouses and acres of picturesque farms. Strollers and wheelchairs are welcome!

The chip-timed 5k race starts and ends near the Leola Produce Auction! After the 5k ends, we will have a kid’s color fun run for children ages 10 & under (registration required). All proceeds benefit the Clinic for Special Children. We hope you can join us!

Race Details

NEW LOCATION! | The chip-timed course starts and ends near the Leola Produce Auction (135 Brethren Church Road, Leola, PA 17540). Parking will be on-site at the Leola Produce Auction, please enter Brethren Church Road from Route 23/East Main Street.

TIMES 9:00 a.m. start for 5k race. Kid’s color fun run following the main 5k race. Race day registration for the 5k race & kid’s color fun run will open at 7:45 a.m. and close promptly at 8:45 a.m.

PACKET PICK-UP | You can pick up your bib and shirt (if applicable) on race day from 7:30 a.m. to 8:45 a.m. at the Leola Produce Auction (135 Brethren Church Road, Leola, PA 17540).

5K ENTRY FEES

$35 by April 21st, includes t-shirt (entry & payment must be received by April 21).

$40 after April 21st (including race day) t-shirt while supplies last.

$10 Kid’s color fun run for ages 10 & under. Kid’s color fun run to start after the end of the 5k race.

HOW TO REGISTER

1. Register online here via the ‘register’ tab.

2. Mail registration form & payment toClinic for Special Children, Attn: 5k Registration, PO Box 500, Intercourse, PA 17534. If paying via check, make payable to: Clinic for Special Children

3. Register in person on race day. Race day registration will be open at 7:30 a.m. and close at 8:45 a.m. at the Leola Produce Auction.

5k AWARDS | Medals will be awarded to the 1st overall male and female finishers. Awards will be given to the top three male and female finishers in the following categories: 14 & under, 15-19, 20-29, 30-39, 40-49, 50-59, 60-69, 70+.

QUESTIONS Contact us at queries@clinicforspecialchildren.org or call 717-687-9407

Race service reserves the right to cancel the race if conditions are deemed unsafe. If canceled, we will consider your registration fee a donation. No refunds, mailed awards, or t-shirts. Results and photos are to be posted on ClinicforSpecialChildren.org/events/5k. Events are subject to change due to severe weather conditions, restrictions, or unforeseen circumstances. Visit www.ClinicforSpecialChildren.org/events/5k for updates.

Insight to Diagnosis: Enjoy our Spring Newsletter!

Our first newsletter of 2025 is here!

This spring edition of the Clinic’s newsletter focuses on intellectual disabilities. We share the story of a patient who has a genetic condition that causes developmental delays, explain what intellectual disability is, and provide a preview of our benefit auction season and Clinic events for this year.

CLICK HERE to read the latest issue now!